Phase boundaries in mixtures of membrane-forming amphiphiles and micelle-forming amphiphiles

Regulation of Sodium Channel Function by Bilayer Elasticity: The Importance of Hydrophobic Coupling. Effects of Micelle-forming Amphiphiles and Cholesterol

Membrane proteins are regulated by the lipid bilayer composition. Specific lipid–protein interactions rarely are involved, which suggests that the regulation is due to changes in some general bilayer property (or properties). The hydrophobic coupling between a membrane-spanning protein and the surrounding bilayer means that protein conformational changes may be associated with a reversible, loc...

Aggregation of Amphiphiles in Ternary Mixtures

We present an improved version of an earlier Larson-type model of amphiphiles. Detailed descriptions of the algorithms are given and some situations where care must be taken are pointed out We use the model to calculate the condensation transition temperature of amphiphiles in a ternary mixture. The concentration percolation threshold and percolation critical exponent of arnphiphile clusters at...

Critical micelle concentration in three-dimensional lattice models of amphiphiles

Amphiphilic molecules with hydrophobic tails and hydrophilic heads form micelles of various shapes and sizes above a minimum threshold concentration known as the critical micelle concentration (CMC). The CMC as well as the size and the shape of the aggregates formed depend on various factors, e.g., the length of the amphiphiles, their internal rigidity, and temperature. In this letter we report...

Wetting in mixtures of water, nonionic amphiphiles, and nonpolar solvents

Tandem facial amphiphiles for membrane protein stabilization.

We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.